Next Generation Sequencing (NGS)
Offered by Scientists at Biomolecular Discovery Services
Biomolecular Discovery Services now offers next-generation sequencing (NGS) in combination with selections based on synthetic, naïve or custom-immunized VHH phage display libraries. Instead of tens or even hundreds of possible leads, NGS provides you with tens of thousands of DNA sequences rank-ordered by their prevalence in the selection. This is especially important when immunodominant sequences repeatedly arise from standard selections.
By making parallel selections, you can discover VHH in common epitopes and unique epitopes and eliminate VHH in tags or fusion proteins. Combined with affinity maturation selections, you can find which residues are critical for improved binding. By altering binding conditions, you can determine which residues the change affects (salt, temperature, epitope mutations).
Contact Us Today for More Information
Contact us today to learn more about our next-generation sequencing and about our knowledgeable scientists. The form is easy to fill out, and we'll happily answer any questions you may have and provide any other information you require before we get started.
Looking for a Different DNA Service from Biomolecular Discovery Services?
Is NGS not quite the service you're looking for? Browse our other services around synthetic and naive libraries or antibody maturation and engineering. Our other services include:
